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KMID : 0378019710140070125
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New Medical Journal
1971 Volume.14 No. 7 p.125 ~ p.132
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Clinical Experience of TM-SMZ(Bactrim) in Various Infections.
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Abstract
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The clinical efficacy of a new antimicrobial, TM-SMZ(Bactrim) in the treatment of various disease: was evaluated in the Dept. of Internal Med., ST. MARY´s Hospital during the period from July 1970, to Feb. 1971. Bacterial cultures and sensitivity tests to antimicrobial agents were performed, in whitcl 525 strains of various bacterias were tested on sensitivity test and 47 systemic cases including Typhok fever(20 cases) were observed on therapeutic efficacy_
In this study, TM-SMZ(Bactrim) was the most sensitive agent to bacteria isolated in variou; infections and their sensitivity rates were as follows: Bactrim. ...82%, Erythromycin ...81%, Kanamyir
71%, Chlortetracycline ...64%, Chloramphenicol "56%, Amphicillin...56%, Oxytetracycline ...47%, Strept￢omycin ???38%, Penicillin ???24%(Tab.2), (Erythromycin is rare by used recently in this area)
Clinical study and its result was obtained on therapeutic efficacy with TM-SMZ in 27 cases of variou: infections including mainly 9 cases of urinary-and 8 cases of biliary infections and 20 cases of Typhoic fever. Overall success rate of Bactrim -therapy was 75%, (exellent and good effect) and average perioc of time taken for defevescence in 20 Typhoid cases was 5. 8 days. Among these, 2 cases were readmittee due to relapse. There were only 2 cases of side reaction(skin rash) of the drug among these 47 case: of this clinical observation.
This new antimicrobial agent; TM-SMZ(Bactrim) is, therefore, an effective drug to various bacteria. infections of gram positive as well as gram negative bacteria, and disclosed that it is an antimicrobia agent of broad spectrum.
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